Graham holds a PhD from the UK Government’s Institute of Food Research and has researched and lectured extensively over the past 10 years on clinical biochemistry, nutrition and folate at the Medical Universities of Sheffield and Nottingham (UK). He was previously Acting Head at the School of Allied Health Science at De Montfort University (DMU) and a DMU Teacher Fellow. As a expert in Clinical Chemistry, and Fellow of the Institute of Biomedical Science he has written and published several journal articles and textbooks on interpreting blood results. Graham has completed the award winning DMU Leadership, Management and Development Programme, as well as a series at BGU from the Leadership Foundation in Higher Education. He is an advocate of authentic, empowered leadership.
Dr Basten is internationally known for his work on how micronutrients modulate the pathophysiology of disease in the context of early-stage bio-markers in non-invasive surrogare tissue. Immediately prior to DMU, he worked with Prof H J Powers (University of Sheffield) in collaboration with Paul Finglas (Institute of Food Research)on the relationship between folate status and biomarkers of cardiovascular disease, cancer and health. The intervention work looked at food intervention vs supplementation using food diaries, 24 hour recall and clinical markers.
In collaboration with Dr S J Duthie (Rowett Research Institute) he validated biomarkers of DNA instability, showed that folate supplementation elicited a significant reduction in uracil misincorporation in healthy people, and developed an automated method to measure folate in lymphocytes and buccal cells.
With Prof S A Watson (University of Nottingham) he showed that hyperplastic polyps have elevated levels of pre-cancerous biomarkers compared with normal resection colorectal samples. In a European Union project co-ordinated by Prof I T Johnson and Prof G Williamson (Institute of Food Research) he investigated the induction of phase II detoxification enzymes (ie human bilirubin UDP-glucuronosyl transferase) and apoptosis by glucosinolate derived isothiocyantes. Also with Prof A J Knox (Nottingham City Hospital) he elucidated how cGMP modulates nitric oxide levels in asthma and cystic fibrosis patients.
Price, S.L., Hardy, S., Gale, P. and Basten, G. (2012) Prevalence of Fusobacterium necrophorum in persistent sore throat samples. British journal of biomedical science, 68 (4), pp. 209-210
Basten, G. (2011) Introduction to Clinical Biochemistry – Interpreting Blood Results. Book Boon (Ventis)
Basten, G. et al (2006) Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. British Journal of Cancer, 94 (12), pp. 1942-1947.
Narayanan, S. et al. (2004) Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil,and DNA methylation status) in human lymphocytes in vivo. Cancer Epidemiology, Biomarkers Prevention, 13, pp. 1436-1443.
Basten, G.; Duthie, S. J.; Hill, M. H.; Powers, H. J. (2004) Effect of folic acid supplementation on the folate status of buccal mucosa and lymphocytes. Cancer Epidemiology, Biomarkers & Prevention, 13 (7), pp. 1244-1249.
Basten, G.; Boa, Y.; Williamson, G. (2002) Sulforaphane amd its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis, 23 (8), pp. 1399-1404.
- Clinical nutrition
- Blood test results / pathology
- CVD (homocysteine and vascular tone) and cancer risk (uracil misincorporation)
- Cell culture, clinical chemistry, molecular biology, vascular tone physiology (exercise)
- Added value, product reformulation, fortification, supplementation and functional foods
- Social nutrition
- Use of validated food diaries and nutrient analysis
- Access to food and food policy
- Community and school meals
- Fellow of the Institute of Biomedical Science (2007-date)
- Member of Phytochemical Society of Europe (2007-date)
- Member of Nutrition Society (2000-2008)
- Fellow of the Higher Education Academy
Dr Basten worked on Pepsico’s wellness programme by reformulating products to contain less sugar and salt.
Dr Basten investigated how social housing, school meals and nutrition effects social aspiration, health and wellness.
Dr Basten co-wrote bids for the 3rd sector East Midlands charity as part of the RIF project and received funding from Sport Relief, One Nottingham and the Big Lottery Fund to allow a community group to develop a healthy cookbook and address health and wellness.